Jace Jones

Jace W. Jones, PhD, is an Associate Professor in the Department of Pharmaceutical Sciences and Associate Director of the Mass Spectrometry Center at the University of Maryland School of Pharmacy.

Headshot of Jace Jones

Jace W. Jones, PhD
Associate ProfessorAssociate Director, Mass Spectrometry CenterDepartment of Pharmaceutical SciencesUniversity of Maryland School of Pharmacy20 N. Pine Street, Room N721Baltimore, MD 21201Phone: 410-706-7598Fax: 410-706-0886Email: jjones@rx.umaryland.eduLab Website | ResearchGate | Scopus | NLM Bibliography

Postdoctoral – Accepting applicants
PhD – Currently recruiting
MS – Currently recruiting

Education

Postdoctoral, Bioanalytical Mass Spectrometry, University of Washington School of Pharmacy

PhD, Analytical Chemistry, University of Washington, Seattle

BS, Biology (chemistry minor) Whitworth University, Spokane, WA

Research Interests

We develop mass spectrometry-based platforms that couple biomarker discovery to quantitative validation. We accomplish our research goals via the use of chromatography, ion mobility, and mass spectrometry to structurally elucidate and quantify biologically active biomolecules to further understand disease/injury mechanism of action and provide novel insight for drug development targets.

About Dr. Jones

Dr. Jones received his PhD in Analytical Chemistry at the University of Washington where he did his thesis research under the supervision of František Tureček. The focus of his thesis was developing gas-phase ion chemistry strategies to gain structural insight into peptides and glycolipids. Dr. Jones then further developed tandem mass spectrometry platforms for structural elucidation of bacterial glycolipids in the laboratory of David R. Goodlett at the University of Washington, School of Pharmacy. At this time, he moved to industry and was the Technical Director at an Analytical Laboratory (Jones Environmental, Inc.) in Fullerton, CA. He made his way back to academic research as a research scientist followed by research assistant professor in the laboratory of Maureen A. Kane at the University of Maryland, School of Pharmacy.

Current Projects

  1. The role of sphingoliplid metabolism in hepatotoxicity
  2. Ether phosphoplipids and oxidative lipidomics in neurodegenerative diseases
  3. Lipid structure/function in bacterial and viral pathogenesis
  4. Oligonucleotide therapeutic structure, impurity, and degradation characterization

Selected Recent Publications

  1. Complete list of publications (>75)
  2. Becette OB, Tran A, Marino JP, Jones JW, Brinson RG. Rapid identification of short oligonucleotide impurities using lithium adduct consolidated MALDI-TOF mass spectrometry. Int. J. Mass Spectrom., 481, 2022, 116913. ISSN 1387-3806. Doi: 10.1016/j.ijms.2022.116913.
  3. Becette OB, Tran A, Jones JW, Marino JP, Brinson RG. Structural Fingerprinting of siRNA Therapeutics by Solution NMR Spectroscopy. Nucleic Acid Ther. 2022 Aug;32(4):267-279. doi: 10.1089/nat.2021.0098. Epub 2022 Mar 9. PubMed PMID: 35263184; PubMed Central PMCID: PMC9416564.
  4. Morel Y, Hegdekar N, Sarkar C, Lipinski MM, Kane MA, Jones JW. Structure-specific, accurate quantitation of plasmalogen glycerophosphoethanolamine. Analytica Chimica Acta, Volume 1186, 2021, 339088, ISSN 0003-2670, doi: 10.1016/j.aca.2021.339088.
  5. Carballal S, Vitvitsky V, Kumar R, Hanna DA, Libiad M, Gupta A, Jones JW, Banerjee R. Hydrogen sulfide stimulates lipid biogenesis from glutamine that is dependent on the mitochondrial NAD(P)H pool. J Biol Chem. 2021 Aug;297(2):100950. doi: 10.1016/j.jbc.2021.100950. Epub 2021 Jul 10. PubMed PMID: 34252456; PubMed Central PMCID: PMC8342795.
  6. Tran A, Monreal IA, Moskovets E, Aguilar HC, Jones JW. Rapid Detection of Viral Envelope Lipids Using Lithium Adducts and AP-MALDI High-Resolution Mass Spectrometry. J Am Soc Mass Spectrom. 2021 Sep 1;32(9):2322-2333. doi: 10.1021/jasms.1c00058. PubMed PMID: 33886294.
  7. Yang N, Parker LE, Yu J, Jones JW, Liu T, Papanicolaou KN, Talbot CC Jr, Margulies KB, O’Rourke B, Kane MA, Foster DB. Cardiac retinoic acid levels decline in heart failure. JCI Insight. 2021 Apr 22;6(8). doi: 10.1172/jci.insight.137593. PubMed PMID: 33724958.
  8. Srikanth MP, Jones JW, Kane M, Awad O, Park TS, Zambidis ET, Feldman RA. Elevated glucosylsphingosine in Gaucher disease induced pluripotent stem cell neurons deregulates lysosomal compartment through mammalian target of rapamycin complex 1. Stem Cells Transl Med. 2021 Mar 3;. doi: 10.1002/sctm.20-0386. PubMed PMID: 33656802.
  9. Tran A, Wan L, Xu Z, Haro JM, Li B, Jones JW. Lithium Hydroxide Hydrolysis Combined with MALDI TOF Mass Spectrometry for Rapid Sphingolipid Detection. J Am Soc Mass Spectrom. 2021 Jan 6;32(1):289-300. doi: 10.1021/jasms.0c00322. Epub 2020 Oct 30. PubMed PMID: 33124427; PubMed Central PMCID: PMC7790884.
  10. Li L, Wang H, Jones JW. Sphingolipid metabolism as a marker of hepatotoxicity in drug-induced liver injury. Prostaglandins Other Lipid Mediat. 2020 Sep 30;151:106484. doi: 10.1016/j.prostaglandins.2020.106484. [Epub ahead of print] PubMed PMID: 33007444.
  11. Sarkar C, Jones JW, Hegdekar N, Thayer JA, Kumar A, Faden AI, Kane MA, Lipinski MM. PLA2G4A/cPLA2-mediated lysosomal membrane damage leads to inhibition of autophagy and neurodegeneration after brain trauma. Autophagy. 2020 Mar;16(3):466-485. doi: 10.1080/15548627.2019.1628538. Epub 2019 Jun 25. PubMed PMID: 31238788; PubMed Central PMCID: PMC6999646.
  12. Jones JW, Sarkar C, Lipinski MM, Kane MA. Detection and Structural Characterization of Ether Glycerophosphoethanolamine from Cortical Lysosomes Following Traumatic Brain Injury Using UPLC-HDMSE. Proteomics. 2019 Sep;19(18):e1800297. doi: 10.1002/pmic.201800297. Epub 2019 Mar 19. PubMed PMID: 30790445; PubMed Central PMCID: PMC7565256.