Research

Natalie Eddington’s research group focuses on pharmacokinetics and applied biopharmaceutic, PK and PD research and how it plays a major role in conducting in vitro, preclinical and clinical research.

Utilizing data analysis techniques including PK modeling, PBPK modeling, lined PK-PD, and population analysis. The PBL performs clinical pharmacology studies including BA, BE, PK, PD and special populations (e.g., renal dysfunction, genetic polymorphism). In addition to performing studies to support INDs, Phase I and Phase II.

Publications

All papers, abstracts, and presentations created by current and former lab members.

Hassan HE, Myers AL, Lee IJ, Chen H, Coop A, Eddington ND. Regulation of gene expression in brain tissues of rats repeatedly treated by the highly abused opioid agonist, oxycodone: microarray profiling and gene mapping analysis. Drug Metab Dispos. 2010 Jan;38(1):157-67. Epub . PubMed PMID: 19786507; PubMed Central PMCID: PMC2802418.

Coles LD, Lee IJ, Voulalas PJ, Eddington ND. Estradiol and progesterone-mediated regulation of P-gp in P-gp overexpressing cells (NCI-ADR-RES) and placental cells (JAR). Mol Pharm. 2009 Nov-Dec;6(6):1816-25. PubMed PMID: 19813763.

Tolson AH, Li H, Eddington ND, Wang H. Methadone induces the expression of hepatic drug-metabolizing enzymes through the activation of pregnane X receptor and constitutive androstane receptor. Drug Metab Dispos. 2009 Sep;37(9):1887-94. Epub 2009 Jun 11. PubMed PMID: 19520773; PubMed Central PMCID: PMC2729327.

Teksin ZS, Lee IJ, Nemieboka NN, Othman AA, Upreti VV, Hassan HE, Syed SS, Prisinzano TE, Eddington ND. Evaluation of the Transport, In Vitro Metabolism and Pharmacokinetics of Salvinorin A, a Potent Hallucinogen. Eur J Pharm Biopharm. 2009 Jan 19. [Epub ahead of print] PubMed PMID: 19602379.

Hassan HE, Mercer SL, Cunningham CW, Coop A, Eddington ND. Evaluation of the P-glycoprotein (Abcb1) affinity status of a series of morphine analogs: comparative study with meperidine analogs to identify opioids with minimal P-glycoprotein interactions. Int J Pharm. 2009 Jun 22;375(1-2):48-54. Epub 2009 Apr 5. PubMed PMID: 19481690.

Teksin ZS, Lee IJ, Nemieboka NN, Othman AA, Upreti VV, Hassan HE, Syed SS, Prisinzano TE, Eddington ND. Evaluation of the transport, in vitro metabolism and pharmacokinetics of Salvinorin A, a potent hallucinogen. Eur J Pharm Biopharm. 2009 Jun;72(2):471-7. PubMed PMID: 19462483; PubMed Central PMCID: PMC2719774.

Hassan HE, Myers AL, Coop A, Eddington ND. Differential involvement of P-glycoprotein (ABCB1) in permeability, tissue distribution, and antinociceptive activity of methadone, buprenorphine, and diprenorphine: in vitro and in vivo evaluation. J Pharm Sci. 2009 Dec;98(12):4928-40. PubMed PMID: 19370547.

Abdel Fattah NS, Hassan HE, Galal ZA, El Okda el SE. Assessment of anti-cyclic citrullinated peptide in psoriatic arthritis. BMC Res Notes. 2009 Mar 19;2:44. PubMed PMID: 19298673; PubMed Central PMCID: PMC2666753.

Coles LD, Lee IJ, Hassan HE, Eddington ND. Distribution of saquinavir, methadone, and buprenorphine in maternal brain, placenta, and fetus during two different gestational stages of pregnancy in mice. J Pharm Sci. 2009 Aug;98(8):2832-46. PubMed PMID: 19116954.

Li L, Stanton JD, Tolson AH, Luo Y, Wang H. Bioactive terpenoids and flavonoids from Ginkgo biloba extract induce the expression of hepatic drug-metabolizing enzymes through pregnane X receptor, constitutive androstane receptor, and aryl hydrocarbon receptor-mediated pathways. Pharm Res. 2009 Apr;26(4):872-82. Epub 2008 Nov 26. PubMed PMID: 19034627; PubMed Central PMCID: PMC2649697.

Cunningham CW, Mercer SL, Hassan HE, Traynor JR, Eddington ND, Coop A. Opioids and efflux transporters. Part 2: P-glycoprotein substrate activity of 3- and 6-substituted morphine analogs. J Med Chem. 2008 Apr 10;51(7):2316-20. Epub 2008 Feb 27. PubMed PMID: 18311899.

Hassan HE, Myers AL, Lee IJ, Coop A, Eddington ND. Oxycodone induces overexpression of P-glycoprotein (ABCB1) and affects paclitaxel’s tissue distribution in Sprague Dawley rats. J Pharm Sci. 2007 Sep;96(9):2494-506. PubMed PMID: 17593551.

Mercer SL, Hassan HE, Cunningham CW, Eddington ND, Coop A. Opioids and efflux transporters. Part 1: P-glycoprotein substrate activity of N-substituted analogs of meperidine. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1160-2. Epub 2006 Dec 21. PubMed PMID: 17251015; PubMed Central PMCID: PMC1850229.

Voulalas PJ, Holtzclaw L, Wolstenholme J, Russell JT, Hyman SE. Metabotropic glutamate receptors and dopamine receptors cooperate to enhance extracellular signal-regulated kinase phosphorylation in striatal neurons. J Neurosci. 2005 Apr 13;25(15):3763-73. PubMed PMID: 15829628.

Hassan HE, Qaim SM, Shubin Y, Azzam A, Morsy M, Coenen HH. Experimental studies and nuclear model calculations on proton-induced reactions on (nat)Se, (76)Se and (77)Se with particular reference to the production of the medically interesting radionuclides (76)Br and (77)Br. Appl Radiat Isot. 2004 Jun;60(6):899-909. PubMed PMID: 15110356.