Selected Publications

Links to selected publications published by Dr. Kane are provided for visitors to explore below.

Retinoic Acid Is a Negative Regulator of sFLT1 Expression in Decidual Stromal Cells, and Its Levels Are Reduced in Preeclamptic Decidua.
Deepak V, Sahu MB, Yu J, Jones JW, Kane MA, Taylor RN, Badell ML, Sidell N, Rajakumar A.
Hypertension. 2019 Mar 18:HYPERTENSIONAHA11812564. doi: 10.1161/HYPERTENSIONAHA.118.12564. [Epub ahead of print]
PMID:30879360

The Novel Mnk1/2 Degrader and Apoptosis Inducer VNLG-152 Potently Inhibits TNBC Tumor Growth and Metastasis.
Ramalingam S, Ramamurthy VP, Gediya LK, Murigi FN, Purushottamachar P, Huang W, Choi EY, Zhang Y, Vasaitis TS, Kane MA, Lapidus RG, Njar VCO.
Cancers (Basel). 2019 Mar 3;11(3). pii: E299. doi: 10.3390/cancers11030299.
PMID:30832411

Detection and Structural Characterization of Ether Glycerophosphoethanolamine from Cortical Lysosomes Following Traumatic Brain Injury Using UPLC-HDMS_E.
Jones JW, Sarkar C, Lipinski MM, Kane MA.
Proteomics. 2019 Feb 20:e1800297. doi: 10.1002/pmic.201800297. [Epub ahead of print]
PMID:30790445

ARS, DEARE, and Multiple-organ Injury: A Strategic and Tactical Approach to Link Radiation Effects, Animal Models, Medical Countermeasures, and Biomarker Development to Predict Clinical Outcome.
MacVittie TJ, Farese AM, Kane MA.
Health Phys. 2019 Apr;116(4):453. doi: 10.1097/HP.0000000000001050. No abstract available.
PMID:30789495

Set of Highly Stable Amine- and Carboxylate-Terminated Dendronized Au Nanoparticles with Dense Coating and Nontoxic Mixed-Dendronized Form.
Saha Ray A, Ghann WE, Tsoi PS, Szychowski B, Dockery LT, Pak YJ, Li W, Kane MA, Swaan P, Daniel MC.
Langmuir. 2019 Mar 5;35(9):3391-3403. doi: 10.1021/acs.langmuir.8b03196. Epub 2019 Feb 18.
PMID:30712354

Effect of Sex on Biomarker Response in a Mouse Model of the Hematopoietic Acute Radiation Syndrome.
Jones JW, Alloush J, Sellamuthu R, Chua HL, MacVittie TJ, Orschell CM, Kane MA.
Health Phys. 2019 Apr;116(4):484-502. doi: 10.1097/HP.0000000000000961.
PMID:30681425

Characterizing the Natural History of Acute Radiation Syndrome of the Gastrointestinal Tract: Combining High Mass and Spatial Resolution Using MALDI-FTICR-MSI.
Carter CL, Hankey KG, Booth C, Tudor GL, Parker GA, Jones JW, Farese AM, MacVittie TJ, Kane MA.
Health Phys. 2019 Apr;116(4):454-472. doi: 10.1097/HP.0000000000000948.
PMID:30681424

Snapshots of Iron Speciation: Tracking the Fate of Iron Nanoparticle Drugs via a Liquid Chromatography-Inductively Coupled Plasma-Mass Spectrometric Approach.
Neu HM, Alexishin SA, Brandis JEP, Williams AMC, Li W, Sun D, Zheng N, Jiang W, Zimrin A, Fink JC, Polli JE, Kane MA, Michel SLJ.
Mol Pharm. 2019 Mar 4;16(3):1272-1281. doi: 10.1021/acs.molpharmaceut.8b01215. Epub 2019 Feb 14.
PMID:30676753

Acute Proteomic Changes in the Lung After WTLI in a Mouse Model: Identification of Potential Initiating Events for Delayed Effects of Acute Radiation Exposure.
Huang W, Yu J, Jones JW, Carter CL, Jackson IL, Vujaskovic Z, MacVittie TJ, Kane MA.
Health Phys. 2019 Apr;116(4):503-515. doi: 10.1097/HP.0000000000000956.
PMID:30652977

Proteomic Evaluation of the Acute Radiation Syndrome of the Gastrointestinal Tract in a Murine Total-body Irradiation Model.
Huang W, Yu J, Jones JW, Carter CL, Pierzchalski K, Tudor G, Booth C, MacVittie TJ, Kane MA.
Health Phys. 2019 Apr;116(4):516-528. doi: 10.1097/HP.0000000000000951.
PMID:30624357

Targeted Metabolomics Reveals Metabolomic Signatures Correlating Gastrointestinal Tissue to Plasma in a Mouse Total-body Irradiation Model.
Jones JW, Clifford Z, Li F, Tudor GL, Farese AM, Booth C, MacVittie TJ, Kane MA.
Health Phys. 2019 Apr;116(4):473-483. doi: 10.1097/HP.0000000000000955.
PMID:30624349

ARS, DEARE, and Multiple-organ Injury: A Strategic and Tactical Approach to Link Radiation Effects, Animal Models, Medical Countermeasures, and Biomarker Development to Predict Clinical Outcome.
MacVittie TJ, Farese AM, Kane MA.
Health Phys. 2019 Mar;116(3):297-304. doi: 10.1097/HP.0000000000001045. No abstract available.
PMID:30608246

Radiation Nephropathy in a Nonhuman Primate Model of Partial-body Irradiation with Minimal Bone Marrow Sparing-Part 1: Acute and Chronic Kidney Injury and the Influence of Neupogen.
Cohen EP, Hankey KG, Farese AM, Parker GA, Jones JW, Kane MA, Bennett A, MacVittie TJ.
Health Phys. 2019 Mar;116(3):401-408. doi: 10.1097/HP.0000000000000960.
PMID:30608245

Prenatal alcohol exposure prevalence as measured by direct ethanol metabolites in meconium in a Native American tribe of the southwest.
Bakhireva LN, Kane MA, Bearer CF, Bautista A, Jones JW, Garrison L, Begay MG, Ozechowski T, Lewis J.
Birth Defects Res. 2019 Jan 15;111(2):53-61. doi: 10.1002/bdr2.1427. Epub 2018 Dec 14.
PMID:30549447

Two functionally redundant sources of retinoic acid secure spermatogonia differentiation in the seminiferous epithelium.
Teletin M, Vernet N, Yu J, Klopfenstein M, Jones JW, Féret B, Kane MA, Ghyselinck NB, Mark M.
Development. 2019 Jan 4;146(1). pii: dev170225. doi: 10.1242/dev.170225.
PMID:30487180

Therapeutic potential of Bcl-x_L/Mcl-1 synthetic inhibitor JY-1-106 and retinoids for human triple-negative breast cancer treatment.
Perri M, Yap JL, Fletcher S, Cione E, Kane MA.
Oncol Lett. 2018 May;15(5):7231-7236. doi: 10.3892/ol.2018.8258. Epub 2018 Mar 14.
PMID:29849791

Alterations in retinoic acid signaling affect the development of the mouse coronary vasculature.
Wang S, Huang W, Castillo HA, Kane MA, Xavier-Neto J, Trainor PA, Moise AR.
Dev Dyn. 2018 Aug;247(8):976-991. doi: 10.1002/dvdy.24639.
PMID:29806219

A subset of mobilized human hematopoietic stem cells express germ layer lineage genes which can be modulated by culture conditions.
Makar T, Nimmagadda VK, Guda PR, Hampton B, Huang W, Kane MA, Fishman PS, Pessac B, Bever CT Jr, Trisler D.
Stem Cell Res Ther. 2018 May 2;9(1):127. doi: 10.1186/s13287-018-0858-5.
PMID:29720239

The Pseudomonas aeruginosa PrrF1 and PrrF2 Small Regulatory RNAs Promote 2-Alkyl-4-Quinolone Production through Redundant Regulation of the antR mRNA.
Djapgne L, Panja S, Brewer LK, Gans JH, Kane MA, Woodson SA, Oglesby-Sherrouse AG.
J Bacteriol. 2018 Apr 24;200(10). pii: e00704-17. doi: 10.1128/JB.00704-17. Print 2018 May 15.
PMID:29507088

The ancestral retinoic acid receptor was a low-affinity sensor triggering neuronal differentiation.
Handberg-Thorsager M, Gutierrez-Mazariegos J, Arold ST, Kumar Nadendla E, Bertucci PY, Germain P, Tomançak P, Pierzchalski K, Jones JW, Albalat R, Kane MA, Bourguet W, Laudet V, Arendt D, Schubert M.
Sci Adv. 2018 Feb 21;4(2):eaao1261. doi: 10.1126/sciadv.aao1261. eCollection 2018 Feb.
PMID:29492455

Retinoic acid signaling promotes the cytoskeletal rearrangement of embryonic epicardial cells.
Wang S, Yu J, Jones JW, Pierzchalski K, Kane MA, Trainor PA, Xavier-Neto J, Moise AR.
FASEB J. 2018 Jul;32(7):3765-3781. doi: 10.1096/fj.201701038R. Epub 2018 Feb 15.
PMID:29447006

LIPG signaling promotes tumor initiation and metastasis of human basal-like triple-negative breast cancer.
Lo PK, Yao Y, Lee JS, Zhang Y, Huang W, Kane MA, Zhou Q.
Elife. 2018 Jan 19;7. pii: e31334. doi: 10.7554/eLife.31334.
PMID:29350614

Effect of Ibuprofen on Skeletal Muscle of Dysferlin-Null Mice.
Collier AF, Gumerson J, Lehtimäki K, Puoliväli J, Jones JW, Kane MA, Manne S, O’Neill A, Windish HP, Ahtoniemi T, Williams BA, Albrecht DE, Bloch RJ.
J Pharmacol Exp Ther. 2018 Mar;364(3):409-419. doi: 10.1124/jpet.117.244244. Epub 2017 Dec 28.
PMID:29284661

Novel galeterone analogs act independently of AR and AR-V7 for the activation of the unfolded protein response and induction of apoptosis in the CWR22Rv1 prostate cancer cell model.
McCarty DJ, Huang W, Kane MA, Purushottamachar P, Gediya LK, Njar VCO.
Oncotarget. 2017 Aug 1;8(51):88501-88516. doi: 10.18632/oncotarget.19762. eCollection 2017 Oct 24.
PMID:29179452

PAMDB: a comprehensive Pseudomonas aeruginosa metabolome database.
Huang W, Brewer LK, Jones JW, Nguyen AT, Marcu A, Wishart DS, Oglesby-Sherrouse AG, Kane MA, Wilks A.
Nucleic Acids Res. 2018 Jan 4;46(D1):D575-D580. doi: 10.1093/nar/gkx1061.
PMID:29106626

Neutrophil microparticle production and inflammasome activation by hyperglycemia due to cytoskeletal instability.
Thom SR, Bhopale VM, Yu K, Huang W, Kane MA, Margolis DJ.
J Biol Chem. 2017 Nov 3;292(44):18312-18324. doi: 10.1074/jbc.M117.802629. Epub 2017 Sep 25.
PMID:28972154

Targeted Metabolomics Identifies Pharmacodynamic Biomarkers for BIO 300 Mitigation of Radiation-Induced Lung Injury.
Jones JW, Jackson IL, Vujaskovic Z, Kaytor MD, Kane MA.
Pharm Res. 2017 Dec;34(12):2698-2709. doi: 10.1007/s11095-017-2200-9. Epub 2017 Oct 2.
PMID:28971289

Planar bile acids in health and disease.
Shiffka SJ, Kane MA, Swaan PW.
Biochim Biophys Acta Biomembr. 2017 Nov;1859(11):2269-2276. doi: 10.1016/j.bbamem.2017.08.019. Epub 2017 Sep 6. Review.
PMID:28887043

Lipidomic dysregulation within the lung parenchyma following whole-thorax lung irradiation: Markers of injury, inflammation and fibrosis detected by MALDI-MSI.
Carter CL, Jones JW, Farese AM, MacVittie TJ, Kane MA.
Sci Rep. 2017 Sep 4;7(1):10343. doi: 10.1038/s41598-017-10396-w.
PMID:28871103

Molecular Basis of Metabolism-Mediated Conversion of PK11195 from an Antagonist to an Agonist of the Constitutive Androstane Receptor.
Mackowiak B, Li L, Welch MA, Li D, Jones JW, Heyward S, Kane MA, Swaan PW, Wang H.
Mol Pharmacol. 2017 Jul;92(1):75-87. doi: 10.1124/mol.117.108621. Epub 2017 Apr 25.
PMID:28442602

The Pseudomonas aeruginosa PrrF Small RNAs Regulate Iron Homeostasis during Acute Murine Lung Infection.
Reinhart AA, Nguyen AT, Brewer LK, Bevere J, Jones JW, Kane MA, Damron FH, Barbier M, Oglesby-Sherrouse AG.
Infect Immun. 2017 Apr 21;85(5). pii: e00764-16. doi: 10.1128/IAI.00764-16. Print 2017 May.
PMID:28289146

Quantifying Kinase-Specific Phosphorylation Stoichiometry Using Stable Isotope Labeling In a Reverse In-Gel Kinase Assay.
Li X, Cox JT, Huang W, Kane M, Tang K, Bieberich CJ.
Anal Chem. 2016 Dec 6;88(23):11468-11475. Epub 2016 Nov 18.
PMID:27808495

Sustained virologic control in SIV+ macaques after antiretroviral and α4β7 antibody therapy.
Byrareddy SN, Arthos J, Cicala C, Villinger F, Ortiz KT, Little D, Sidell N, Kane MA, Yu J, Jones JW, Santangelo PJ, Zurla C, McKinnon LR, Arnold KB, Woody CE, Walter L, Roos C, Noll A, Van Ryk D, Jelicic K, Cimbro R, Gumber S, Reid MD, Adsay V, Amancha PK, Mayne AE, Parslow TG, Fauci AS, Ansari AA.
Science. 2016 Oct 14;354(6309):197-202.
PMID:27738167

Quantitation of the Noncovalent Cellular Retinol-Binding Protein, Type 1 Complex Through Native Mass Spectrometry.
Li W, Yu J, Kane MA.
J Am Soc Mass Spectrom. 2017 Jan;28(1):29-37. doi: 10.1007/s13361-016-1499-5. Epub 2016 Oct 5.
PMID:27709511

Ultraperformance convergence chromatography-high resolution tandem mass spectrometry for lipid biomarker profiling and identification.
Jones JW, Carter CL, Li F, Yu J, Pierzchalski K, Jackson IL, Vujaskovic Z, Kane MA.
Biomed Chromatogr. 2017 Mar;31(3). doi: 10.1002/bmc.3822. Epub 2016 Sep 29.
PMID:27557409

Cystic Fibrosis Isolates of Pseudomonas aeruginosa Retain Iron-Regulated Antimicrobial Activity against Staphylococcus aureus through the Action of Multiple Alkylquinolones.
Nguyen AT, Jones JW, Cámara M, Williams P, Kane MA, Oglesby-Sherrouse AG.
Front Microbiol. 2016 Jul 27;7:1171. doi: 10.3389/fmicb.2016.01171. eCollection 2016.
PMID:27512392

Col1a1+ perivascular cells in the brain are a source of retinoic acid following stroke.
Kelly KK, MacPherson AM, Grewal H, Strnad F, Jones JW, Yu J, Pierzchalski K, Kane MA, Herson PS, Siegenthaler JA.
BMC Neurosci. 2016 Jul 15;17(1):49. doi: 10.1186/s12868-016-0284-5.
PMID:27422020

Blocking the PAH2 domain of Sin3A inhibits tumorigenesis and confers retinoid sensitivity in triple negative breast cancer.
Bansal N, Bosch A, Leibovitch B, Pereira L, Cubedo E, Yu J, Pierzchalski K, Jones JW, Fishel M, Kane M, Zelent A, Waxman S, Farias E.
Oncotarget. 2016 Jul 12;7(28):43689-43702. doi: 10.18632/oncotarget.9905.
PMID:27286261

Inflation-Fixation Method for Lipidomic Mapping of Lung Biopsies by Matrix Assisted Laser Desorption/Ionization-Mass Spectrometry Imaging.
Carter CL, Jones JW, Farese AM, MacVittie TJ, Kane MA.
Anal Chem. 2016 May 3;88(9):4788-94. doi: 10.1021/acs.analchem.6b00165. Epub 2016 Apr 19.
PMID:27028398

Polydimethylsiloxane (PDMS) modulates CD38 expression, absorbs retinoic acid and may perturb retinoid signalling.
Futrega K, Yu J, Jones JW, Kane MA, Lott WB, Atkinson K, Doran MR.
Lab Chip. 2016 Apr 21;16(8):1473-83. doi: 10.1039/c6lc00269b.
PMID:27008339

Electron-induced dissociation (EID) for structure characterization of glycerophosphatidylcholine: determination of double-bond positions and localization of acyl chains.
Jones JW, Thompson CJ, Carter CL, Kane MA.
J Mass Spectrom. 2015 Dec;50(12):1327-39. doi: 10.1002/jms.3698.
PMID: 26634966

A MALDI-MSI Approach to the Characterization of Radiation-Induced Lung Injury and Medical Countermeasure Development.
Carter CL, Jones JW, Barrow K, Kieta K, Taylor-Howell C, Kearney S, Smith CP, Gibbs A, Farese AM, MacVittie TJ, Kane MA.
Health Phys. 2015 Nov;109(5):466-78. doi: 10.1097/HP.0000000000000353.
PMID: 26425906

Citrulline as a Biomarker in the Murine Total-Body Irradiation Model: Correlation of Circulating and Tissue Citrulline to Small Intestine Epithelial Histopathology.
Jones JW, Tudor G, Li F, Tong Y, Katz B, Farese AM, MacVittie TJ, Booth C, Kane MA.
Health Phys. 2015 Nov;109(5):452-65. doi: 10.1097/HP.0000000000000346.
PMID: 26425905

Citrulline as a Biomarker in the Non-human Primate Total- and Partial-body Irradiation Models: Correlation of Circulating Citrulline to Acute and Prolonged Gastrointestinal Injury.
Jones JW, Bennett A, Carter CL, Tudor G, Hankey KG, Farese AM, Booth C, MacVittie TJ, Kane MA.
Health Phys. 2015 Nov;109(5):440-51. doi: 10.1097/HP.0000000000000347.
PMID: 26425904

Effect of Common Excipients on the Oral Drug Absorption of Biopharmaceutics Classification System Class 3 Drugs Cimetidine and Acyclovir.
Vaithianathan S, Haidar SH, Zhang X, Jiang W, Avon C, Dowling TC, Shao C, Kane M, Hoag SW, Flasar MH, Ting TY, Polli JE.
J Pharm Sci. 2015 Sep 16. doi: 10.1002/jps.24643. [Epub ahead of print]
PMID: 26375604

Generic lamotrigine versus brand-name Lamictal bioequivalence in patients with epilepsy: A field test of the FDA bioequivalence standard.
Ting TY, Jiang W, Lionberger R, Wong J, Jones JW, Kane MA, Krumholz A, Temple R, Polli JE.
Epilepsia. 2015 Sep;56(9):1415-24. doi: 10.1111/epi.13095. Epub 2015 Jul 23.
PMID: 26201987

Pathogenesis of Endometriosis: Roles of Retinoids and Inflammatory Pathways.
Taylor RN, Kane MA, Sidell N.
Semin Reprod Med. 2015 Jul;33(4):246-56. doi: 10.1055/s-0035-1554920. Epub 2015 Jul 1.
PMID: 26132929

All-Trans Retinoic Acid Activity in Acute Myeloid Leukemia: Role of Cytochrome P450 Enzyme Expression by the Microenvironment.
Su M, Alonso S, Jones JW, Yu J, Kane MA, Jones RJ, Ghiaur G.
PLoS One. 2015 Jun 5;10(6):e0127790. doi: 10.1371/journal.pone.0127790. eCollection 2015.
PMID: 26047326

Surgical Management of Caseous Calcification of the Mitral Annulus.
Wehman B, Dawood M, Ghoreishi M, Cheema F, Jones JW, Kane MA, Ward CW, Gammie JS.
Ann Thorac Surg. 2015 Jun;99(6):2231-3. doi: 10.1016/j.athoracsur.2015.02.106.
PMID:26046892

Biopharmaceutic Risk Assessment of Brand and Generic Lamotrigine Tablets.
Vaithianathan S, Raman S, Jiang W, Ting TY, Kane MA, Polli JE.
Mol Pharm. 2015 Jul 6;12(7):2436-43. doi: 10.1021/acs.molpharmaceut.5b00154. Epub 2015 Jun 2.
PMID: 26001027

Species-specific differences in the expression and regulation of α4β7 integrin in various nonhuman primates.
Byrareddy SN, Sidell N, Arthos J, Cicala C, Zhao C, Little DM, Dunbar P, Yang GX, Pierzchalski K, Kane MA, Mayne AE, Song B, Soares MA, Villinger F, Fauci AS, Ansari AA.
J Immunol. 2015 Jun 15;194(12):5968-79. doi: 10.4049/jimmunol.1402866. Epub 2015 May 6.
PMID: 25948815

Iron Depletion Enhances Production of Antimicrobials by Pseudomonas aeruginosa.
Nguyen AT, Jones JW, Ruge MA, Kane MA, Oglesby-Sherrouse AG.
J Bacteriol. 2015 Jul;197(14):2265-75. doi: 10.1128/JB.00072-15. Epub 2015 Apr 27.
PMID: 25917911

A role for retinoids in human oocyte fertilization: regulation of connexin 43 by retinoic acid in cumulus granulosa cells.
Best MW, Wu J, Pauli SA, Kane MA, Pierzchalski K, Session DR, Woods DC, Shang W, Taylor RN, Sidell N.
Mol Hum Reprod. 2015 Jun;21(6):527-34. doi: 10.1093/molehr/gav017. Epub 2015 Apr 15.
PMID: 25877907

Use of fast HPLC multiple reaction monitoring cubed for endogenous retinoic acid quantification in complex matrices.
Jones JW, Pierzchalski K, Yu J, Kane MA.
Anal Chem. 2015 Mar 17;87(6):3222-30. doi: 10.1021/ac504597q. Epub 2015 Mar 9.
PMID: 25704261

Choline partially prevents the impact of ethanol on the lipid raft dependent functions of l1 cell adhesion molecule.
Tang N, Bamford P, Jones J, He M, Kane MA, Mooney SM, Bearer CF.
Alcohol Clin Exp Res. 2014 Nov;38(11):2722-30. doi: 10.1111/acer.12554.
PMID: 25421509

A mollusk retinoic acid receptor (RAR) ortholog sheds light on the evolution of ligand binding.
Gutierrez-Mazariegos J, Nadendla EK, Lima D, Pierzchalski K, Jones JW, Kane M, Nishikawa J, Hiromori Y, Nakanishi T, Santos MM, Castro LF, Bourguet W, Schubert M, Laudet V.
Endocrinology. 2014 Nov;155(11):4275-86. doi: 10.1210/en.2014-1181. Epub 2014 Aug 13.
PMID: 25116705

Quantification of lamotrigine in patient plasma using a fast liquid chromatography-tandem mass spectrometry method with backflush technology.
Wong JM, Jones JW, Jiang W, Polli JE, Kane MA.
Ther Drug Monit. 2015 Apr;37(2):188-97. doi: 10.1097/FTD.0000000000000123.
PMID: 25162213

Retinoic acid biosynthesis is impaired in human and murine endometriosis.
Pierzchalski K, Taylor RN, Nezhat C, Jones JW, Napoli JL, Yang G, Kane MA, Sidell N.
Biol Reprod. 2014 Oct;91(4):84. doi: 10.1095/biolreprod.114.119677. Epub 2014 Aug 20.
PMID: 25143356

BCL-xL/MCL-1 inhibition and RARγ antagonism work cooperatively in human HL60 leukemia cells.
Perri M, Yap JL, Yu J, Cione E, Fletcher S, Kane MA.
Exp Cell Res. 2014 Oct 1;327(2):183-91. doi: 10.1016/j.yexcr.2014.07.024. Epub 2014 Aug 1.
PMID: 25088254

Effects of diet and strain on mouse serum and tissue retinoid concentrations.
Obrochta KM, Kane MA, Napoli JL.
PLoS One. 2014 Jun 9;9(6):e99435. doi: 10.1371/journal.pone.0099435. eCollection 2014.
PMID: 24911926

Development and validation of a LC-MS/MS assay for quantitation of plasma citrulline for application to animal models of the acute radiation syndrome across multiple species.
Jones JW, Tudor G, Bennett A, Farese AM, Moroni M, Booth C, MacVittie TJ, Kane MA.
Anal Bioanal Chem. 2014 Jul;406(19):4663-75. doi: 10.1007/s00216-014-7870-0. Epub 2014 May 20
PMID: 24842404

MALDI-MSI: Biomarker Discovery for Radiation Exposures
Carter CL, MacVittie TJ, Kane MA
THREE Encyclopedia, Systems Biology (March 24) 2014. http://three.usra.edu/

Mass spectrometry imaging enriches biomarker discovery approaches with candidate mapping.
Scott AJ, Jones JW, Orschell CM, MacVittie TJ, Kane MA, Ernst RK.
Health Phys. 2014 Jan;106(1):120-8. doi: 10.1097/HP.0b013e3182a4ec2f.
PMID: 24276555

Identification and quantitation of biomarkers for radiation-induced injury via mass spectrometry.
Jones JW, Scott AJ, Tudor G, Xu PT, Jackson IL, Vujaskovic Z, Booth C, MacVittie TJ, Ernst RK, Kane MA.
Health Phys. 2014 Jan;106(1):106-19. doi: 10.1097/HP.0b013e3182a4ed3b.
PMID: 24276554

The retinaldehyde reductase DHRS3 is essential for preventing the formation of excess retinoic acid during embryonic development.
Billings SE, Pierzchalski K, Butler Tjaden NE, Pang XY, Trainor PA, Kane MA, Moise AR.
FASEB J. 2013 Dec;27(12):4877-89. doi: 10.1096/fj.13-227967. Epub 2013 Sep 4.
PMID:24005908

Disruption of Myc-Max heterodimerization with improved cell-penetrating analogs of the small molecule 10074-G5.
Wang H, Chauhan J, Hu A, Pendleton K, Yap JL, Sabato PE, Jones JW, Perri M, Yu J, Cione E, Kane MA, Fletcher S, Prochownik EV.
Oncotarget. 2013 Jun;4(6):936-47.
PMID:23801058

Erratum: Disruption of Myc-Max Heterodimerization with Improved Cell-Penetrating Analogs of the Small Molecule 10074-G5.
Wang H, Chauhan J, Hu A, Pendleton K, Yap JL, Sabato PE, Jones JW, Perri M, Yu J, Cione E, Kane MA, Fletcher S, Prochownik EV.
Oncotarget. 2018 Oct 12;9(80):35196. doi: 10.18632/oncotarget.26241. eCollection 2018 Oct 12.
PMID:30416689

Synthesis, modeling, and pharmacological evaluation of UMB 425, a mixed μ agonist/δ antagonist opioid analgesic with reduced tolerance liabilities.
Healy JR, Bezawada P, Shim J, Jones JW, Kane MA, MacKerell AD Jr, Coop A, Matsumoto RR.
ACS Chem Neurosci. 2013 Sep 18;4(9):1256-66. doi: 10.1021/cn4000428. Epub 2013 Jun 11.
PMID: 23713721

Analysis of follicular fluid retinoids in women undergoing in vitro fertilization: retinoic acid influences embryo quality and is reduced in women with endometriosis.
Pauli SA, Session DR, Shang W, Easley K, Wieser F, Taylor RN, Pierzchalski K, Napoli JL, Kane MA, Sidell N.
Reprod Sci. 2013 Sep;20(9):1116-24. doi: 10.1177/1933719113477487. Epub 2013 Feb 20.
PMID: 23427183

CrbpI regulates mammary retinoic acid homeostasis and the mammary microenvironment.
Pierzchalski K, Yu J, Norman V, Kane MA.
FASEB J. 2013 May;27(5):1904-16. doi: 10.1096/fj.12-219410. Epub 2013 Jan 29.
PMID: 23362116

Quantification of Acyclovir in Human Plasma by Ultra-High-Performance Liquid Chromatography-Heated Electrospray Ionization-Tandem Mass Spectrometry for Bioequivalence Evaluation.
C Shao, TC Dowling, S Haidar, LX Yu, JE Polli, MA Kane
Journal of Analytical & Bioanalytical Techniques 2012, 3 (4).

Morphological defects in a novel Rdh10 mutant that has reduced retinoic acid biosynthesis and signaling.
Ashique AM, May SR, Kane MA, Folias AE, Phamluong K, Choe Y, Napoli JL, Peterson AS.
Genesis. 2012 May;50(5):415-23. doi: 10.1002/dvg.22002. Epub 2012 Jan 25.
PMID: 22162152

Analysis, occurrence, and function of 9-cis-retinoic acid.
Kane MA.
Biochim Biophys Acta. 2012 Jan;1821(1):10-20. doi: 10.1016/j.bbalip.2011.09.012. Epub 2011 Oct 1. Review.
PMID: 21983272

CrbpI modulates glucose homeostasis and pancreas 9-cis-retinoic acid concentrations.
Kane MA, Folias AE, Pingitore A, Perri M, Krois CR, Ryu JY, Cione E, Napoli JL.
Mol Cell Biol. 2011 Aug;31(16):3277-85. doi: 10.1128/MCB.05516-11. Epub 2011 Jun 13.
PMID: 21670153

MyD88 and retinoic acid signaling pathways interact to modulate gastrointestinal activities of dendritic cells.
Villablanca EJ, Wang S, de Calisto J, Gomes DC, Kane MA, Napoli JL, Blaner WS, Kagechika H, Blomhoff R, Rosemblatt M, Bono MR, von Andrian UH, Mora JR.
Gastroenterology. 2011 Jul;141(1):176-85. doi: 10.1053/j.gastro.2011.04.010. Epub 2011 Apr 16.
PMID: 21596042

Binding affinities of CRBPI and CRBPII for 9-cis-retinoids.
Kane MA, Bright FV, Napoli JL.
Biochim Biophys Acta. 2011 May;1810(5):514-8. doi: 10.1016/j.bbagen.2011.02.009. Epub 2011 Mar 5.
PMID: 21382444

In vivo magnetic resonance imaging to detect biliary excretion of 19F-labeled drug in mice.
Raufman JP, Xu S, Cheng K, Khurana S, Johnson D, Shao C, Kane MA, Shi D, Gullapalli R, Polli J.
Drug Metab Dispos. 2011 May;39(5):736-9. doi: 10.1124/dmd.110.037358. Epub 2011 Jan 26.
PMID: 21270105

Multiple retinol and retinal dehydrogenases catalyze all-trans-retinoic acid biosynthesis in astrocytes.
Wang C, Kane MA, Napoli JL.
J Biol Chem. 2011 Feb 25;286(8):6542-53. doi: 10.1074/jbc.M110.198382. Epub 2010 Dec 7.
PMID: 21138835

Identification of 9-cis-retinoic acid as a pancreas-specific autacoid that attenuates glucose-stimulated insulin secretion.
Kane MA, Folias AE, Pingitore A, Perri M, Obrochta KM, Krois CR, Cione E, Ryu JY, Napoli JL.
Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21884-9. doi: 10.1073/pnas.1008859107. Epub 2010 Nov 29.
PMID: 21115832

Endogenous retinoids in mammalian growth plate cartilage: analysis and roles in matrix homeostasis and turnover.
Williams JA, Kane M, Okabe T, Enomoto-Iwamoto M, Napoli JL, Pacifici M, Iwamoto M.
J Biol Chem. 2010 Nov 19;285(47):36674-81. doi: 10.1074/jbc.M110.151878. Epub 2010 Sep 14.
PMID: 20843807

Altered retinoic acid metabolism in diabetic mouse kidney identified by O isotopic labeling and 2D mass spectrometry.
Starkey JM, Zhao Y, Sadygov RG, Haidacher SJ, Lejeune WS, Dey N, Luxon BA, Kane MA, Napoli JL, Denner L, Tilton RG.
PLoS One. 2010 Jun 14;5(6):e11095. doi: 10.1371/journal.pone.0011095.
PMID: 20559430

Quantification of endogenous retinoids.
Kane MA, Napoli JL.
Methods Mol Biol. 2010;652:1-54. doi: 10.1007/978-1-60327-325-1_1.
PMID: 20552420

Vitamin A facilitates enteric nervous system precursor migration by reducing Pten accumulation.
Fu M, Sato Y, Lyons-Warren A, Zhang B, Kane MA, Napoli JL, Heuckeroth RO.
Development. 2010 Feb;137(4):631-40. doi: 10.1242/dev.040550.
PMID: 20110328

Retinoic acid is a cofactor for translational regulation of vascular endothelial growth factor in human endometrial stromal cells.
Sidell N, Feng Y, Hao L, Wu J, Yu J, Kane MA, Napoli JL, Taylor RN.
Mol Endocrinol. 2010 Jan;24(1):148-60. doi: 10.1210/me.2009-0155. Epub 2009 Nov 12.
PMID: 19910455

Ethanol elevates physiological all-trans-retinoic acid levels in select loci through altering retinoid metabolism in multiple loci: a potential mechanism of ethanol toxicity.
Kane MA, Folias AE, Wang C, Napoli JL.
FASEB J. 2010 Mar;24(3):823-32. doi: 10.1096/fj.09-141572. Epub 2009 Nov 4.
PMID: 19890016

Retinoic acid from the meninges regulates cortical neuron generation.
Siegenthaler JA, Ashique AM, Zarbalis K, Patterson KP, Hecht JH, Kane MA, Folias AE, Choe Y, May SR, Kume T, Napoli JL, Peterson AS, Pleasure SJ.
Cell. 2009 Oct 30;139(3):597-609. doi: 10.1016/j.cell.2009.10.004. Erratum in: Cell. 2011 Aug 5;146(3):486.
PMID: 19879845

Rdh12 activity and effects on retinoid processing in the murine retina.
Chrispell JD, Feathers KL, Kane MA, Kim CY, Brooks M, Khanna R, Kurth I, Hübner CA, Gal A, Mears AJ, Swaroop A, Napoli JL, Sparrow JR, Thompson DA.
J Biol Chem. 2009 Aug 7;284(32):21468-77. doi: 10.1074/jbc.M109.020966. Epub 2009 Jun 8.
PMID: 19506076

Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.
Williams JA, Kondo N, Okabe T, Takeshita N, Pilchak DM, Koyama E, Ochiai T, Jensen D, Chu ML, Kane MA, Napoli JL, Enomoto-Iwamoto M, Ghyselinck N, Chambon P, Pacifici M, Iwamoto M.
Dev Biol. 2009 Apr 15;328(2):315-27. doi: 10.1016/j.ydbio.2009.01.031. Epub 2009 Feb 3.
PMID: 19389355

Retinol Esterification by DGAT1 Is Essential for Retinoid Homeostasis in Murine Skin.
Shih MY, Kane MA, Zhou P, Yen CL, Streeper RS, Napoli JL, Farese RV Jr.
J Biol Chem. 2009 Feb 13;284(7):4292-9. doi: 10.1074/jbc.M807503200. Epub 2008 Nov 20.
PMID: 19028692

HPLC/UV quantitation of retinal, retinol, and retinyl esters in serum and tissues.
Kane MA, Folias AE, Napoli JL.
Anal Biochem. 2008 Jul 1;378(1):71-9. doi: 10.1016/j.ab.2008.03.038. Epub 2008 Mar 25.
PMID: 18410739

Quantitative profiling of endogenous retinoic acid in vivo and in vitro by tandem mass spectrometry.
Kane MA, Folias AE, Wang C, Napoli JL.
Anal Chem. 2008 Mar 1;80(5):1702-8. doi: 10.1021/ac702030f. Epub 2008 Feb 6.
PMID: 18251521

Altered vitamin A homeostasis and increased size and adiposity in the rdh1-null mouse.
Zhang M, Hu P, Krois CR, Kane MA, Napoli JL.
FASEB J. 2007 Sep;21(11):2886-96. Epub 2007 Apr 13.
PMID: 17435174

Quantification of endogenous retinoic acid in limited biological samples by LC/MS/MS.
Kane MA, Chen N, Sparks S, Napoli JL.
Biochem J. 2005 May 15;388(Pt 1):363-9.
PMID:15628969

W.E. Gardinier, M.A. Kane, F.V. Bright, “Effects of added CO₂ on the dynamics of poly(dimethylsiloxane) oligomers dissolved in a q solvent and a poor Solvent” J. Phys. Chem. B. 2004, 108, 18520-18529.

C.M. Cardona, T. Wilkes, W. Ong, A.E. Kaifer, T.D. McCarley, S. Pandey, G.A. Baker, M.A. Kane, S.N. Baker, F.V. Bright, “Dendrimers functionalized with a single pyrene label: synthesis, photophysics, and fluorescence quenching” J. Phys. Chem. B. 2002, 106, 8649-8656.

S. Pandey, M.A. Kane, G.A. Baker, F.V. Bright, A. Fürstner,G. Seidel, W. Leitner, “The photophysics of 6-(1-pyrenyl)hexyl-11(1-pyrenyl)undecanoate in neat liquids and supercritical carbon dioxide: impact on olefin metathesis” J.Phys. Chem. B. 2002, 106, 1820-1832.

Effects of fluorescent probe structure on the dynamics at cysteine-34 within bovine serum albumin: evidence for probe-dependent modulation of the cybotactic region.
Baker GA, Pandey S, Kane MA, Maloney TD, Hartnett AM, Bright FV.
Biopolymers. 2001 Dec;59(7):502-11.
PMID:11745116

S.N. Baker, G.A. Baker, M.A. Kane, F.V. Bright, “The cybotactic region surrounding fluorescent probes dissolved in 1-butyl-3-methylimidazolium hexafluorophosphate: effects of temperature and added carbon dioxide” J. Phys. Chem. B 2001, 105, 9663-9668.

M.A. Kane, S. Pandey, G.A. Baker, S.A. Perez, E.J. Bukowski, D.C. Hoth, F.V. Bright, “Effects of density on the intramolecular hydrogen bonding, tail-tail cyclization, and mean-free tail-to-tail distances of pyrene end-labeled poly(dimethylsiloxane) oligomers dissolved in supercritical CO₂” Macromolecules 2001, 34, 6831-6838.

C.A. Munson, M.A. Kane, G.A. Baker, S.A. Perez, F.V. Bright, “Three-arm poly(dimethylsiloxane) junction bearing a single pendant dansyl group: a model architecture for polymer junction points dissolved in liquids and molten polymers” Macromolecules 2001, 34, 4624-4629.

S. Pandey, G.A. Baker, M.A. Kane, N.J. Bonzagni, F.V. Bright, “On the microenvironment surrounding dansyl sequestered within class I and II xerogels” Chem. Mater. 2000, 12, 3547-3551.

G.A. Baker, M.A. Kane, S. Pandey, F.V. Bright with J.D. Brennan, K. Flora, and G. N. Bendiak, “Probing the origins of spectroscopic responses to analyte-induced conformational changes in fluorescently-labeled cod III parvalbumin” J. Phys. Chem. B 2000, 104, 10100-10110.

M.A. Kane, G.A. Baker, S. Pandey, F.V. Bright, “Effect of carbon dioxide pressure on the intramolecular dynamics of pyrene-labeled poly(dimethylsiloxane) in liquid toluene” J. Phys. Chem. B 2000 , 104, 8585-8591.

S. Pandey, G.A. Baker, M.A. Kane, F.V. Bright, “O₂quenching of ruthenium (II) tris(2,2′ bypyridyl)²⁺ within the water pool of perfluoropolyether-based reverse micelles formed in supercritical carbon dioxide” Langmuir 2000, 16, 5593-5599.

M.A. Kane, G.A. Baker, S. Pandey, F.V. Bright, “Performance of cholesterol oxidase sequestered within reverse micelles formed in supercritical carbon dioxide” Langmuir 2000, 16, 4901-4905.

S. Pandey, G.A. Baker, M.A. Kane, F.V. Bright. “On the weak intrinsic luminescence from paclitaxel dissolved in nonelectrolyte solvents” Appl. Spectrosc. 1999, 53, 991-999.