Brooke Langevin, PhD, is an Assistant Professor in the Department of Practice, Sciences, and Health Outcomes Research.
Dr. Langevin is a pharmacometrician and translational scientist whose work focuses on applying quantitative modeling and simulation to inform drug development and optimize pharmacotherapy across special populations. Her research integrates population pharmacokinetics (pop-PK), physiologically based pharmacokinetic (PBPK) modeling, and data-driven decision frameworks to better understand drug exposure in populations such as pregnant individuals, infants, and patients with obesity. She brings experience across academia and industry, with a strong emphasis on advancing precision dosing and improving therapeutic outcomes through model-informed drug development.
Research Interests
- Population and physiologically based pharmacokinetic (PK) modeling
- Model-informed drug development and precision dosing
- Pharmacokinetics in special populations (pregnancy, pediatrics, obesity)
- Translational pharmacology and simulation-based decision frameworks
- Exposure-response relationships and drug optimization
Education and Training
- PhD: Pharmaceutical Sciences, University of Maryland, Baltimore
- BS: Chemical and Biomolecular Engineering, Johns Hopkins University
Professional Experience
- Assistant Professor, University of Maryland School of Pharmacy (2025–Present)
- Graduate Research Assistant, University of Maryland School of Pharmacy (2021–2025)
- Clinical Pharmacology Intern, AbbVie Inc.
- Research Intern, University of Maryland School of Pharmacy
- Pharmacometrics Intern, Janssen Pharmaceutical Companies of Johnson & Johnson
Selected Research Contributions
- Developed population PK models to characterize drug and metabolite exposure in diverse patient populations
- Led modeling efforts examining intergenerational transmission of low-calorie sweeteners through breast milk
- Designed PBPK models and decision frameworks to guide pharmacokinetic studies in pregnant and obese populations
- Conducted model-based extrapolation of drug dosing from adults to pediatric populations
- Applied non-compartmental and nonlinear mixed effects modeling to evaluate drug distribution and exposure
Selected Publications
- Langevin B. et al. (2023). The MILK study: Intergenerational transmission of low-calorie sweeteners. Contemporary Clinical Trials Communications.
- Langevin B. et al. (2023). Drug prioritization framework for pharmacokinetic trials in obesity. Journal of Clinical Pharmacology.
- Sylvetsky AC et al. (2024). Transmission of sweeteners through human milk. American Journal of Clinical Nutrition.
- Langevin B. et al. (2023). Pharmacokinetics and biodistribution of prostaglandin E2 analogs. Radiation Research.
Teaching and Mentorship
- Instructor for workshops on pharmacometric modeling and simulation using Pumas software
- Teaching Assistant for multiple graduate-level pharmacometrics and pharmacokinetics courses
- Mentor to graduate and professional students in modeling, data analysis, and translational research
Honors and Awards
- ACOP Clinical Pharmacology SIG Award (2025)
- ACCP Student & Trainee Abstract Awards (2020, 2023)