My laboratory at the University of Maryland School of Pharmacy has fully equipped modern research laboratories for analytical, preformulation, formulation research; suites for non-clinical manufacturing research and development and some GMP manufacturing capabilities.
All of the above mentioned facilities and other facilities on campus are readily available for all personnel working on a project.
Preformulation:
- Thermal analysis:
- DSC and MDSC
- Solubility:
- Viscosity measurement
- pH and ion selective techniques
- Osmolarity
- Moisture content:
- Carl Fisher titration
- Loss on drying (LOD)
- Moisture adsorption isotherm determination
Mechanical Characterization:
- Instron
- Flow Characterization
- Annular shear cell
- Angle of repose
- Carr index
- Minimum orifice diameter
Density Characterization:
- Bulk density
- Tapped density
- True density
Capsule Filling Machines:
- Zansi LZ64
- Harro Hofliger-KFM/3 Model
Dry Granulation:
- Roller Compactor Model Model P120V Alexanderwerk
- Powder Characterization
- Particle size:
- Laser diffraction (dynamic and static)
- Microscopy
- SEM
- Sieve analysis
- Surface area
- Porosity measurement
USP & Non-USP Test Capabilities:
- Foss NIR Spectrophotometer RCA 6500
- Weight variation
- Content variation
- Tablet disintegration
- Tablet dissolution for IR and CR
- Tablet hardness
Tableting:
- Stoke’s B2 Rotary Tablet Press (16 stations)
- Instrumented compression and ejection
- Colton Single Station Tablet
- Fully Instrumented upper and lower force and displacement
- Manesty Beta Press
- High speed rotary tablet press (16 stations)
- Tableting Test capabilities
- Heckel analysis
- Elasticity and other standard tests
- B2 Stokes Tablet Press
- Manesty Betapress
Coating:
- Niro-Aeromatic MP-1 Fluid Bed Processor
- Hi-Coater HT-30
- For small clinical lots – ca 1 kg capacity
- Freund Model HCT-30 Hi-Coater
Analytical:
- UV/Vis Spectrophotometer
- HPLC
- HPLC-MS
- GC
- GC-MS
Miscellaneous Equipment:
- Environmental chambers for stability
- Temperature and humidity
- Granulation equipment: high shear, low shear and fluid bed
- Vacuum drying
- Milling: hammer and fluid energy
Blending Equipment:
- Niro-Fielder GP-1 (high shear granulator)
- 5 cu ft PK V-Blender
- 16qt V-Blender
- 8qt V-Blender
- Milling Equipment:
- Quadro Comil 197S (development / clinical scale)
Dissolution System:
- (1) SR8 Plus Dissolution Test Station (2) with VK8000 autosampler
- Malvern Mastersizer
- Extrusion Spheronization