PUBLICATIONS, BOOK CHAPTERS AND CONFERENCE PROCEEDINGS

 Selected Publications in Peer-reviewed Journals 

 

# indicates shared first author, *Indicates corresponding OR co-corresponding author

Soo Hyeon Shin, Priyanka Ghosh, Bryan Newman, Dana C. Hammell, Sam G. Raney, Hazem E. Hassan*, Audra L. Stinchcomb*. On the Road to Development of an In Vitro Permeation Test (IVPT) Model to Compare Heat Effects on Transdermal Delivery Systems: Exploratory Studies with Nicotine and Fentanyl. Pharmaceutical Research, In Press

Hazem E. Hassan#, Deanna Kelly#, Moshe Honick, Sagar Shukla, Ahmed Ibrahim, David A. Gorelick, Matthew Glassman, Robert P. McMahon, Heidi J. Wehring, Ann Marie Kearns, Stephanie Feldman, Mingming Yu, Ken Bauer, Jia Bei Wang*. Pharmacokinetics and Safety Assessment of L-Tetrahydropalmatine in Cocaine Users: A Randomized, Double-blind, Placebo Controlled Study. Journal of Clinical Pharmacology. 2017 Feb;57(2):151-160. Editor’s Choice –February 2017 Issue.

David S. Nakhla, Lobna A. Hussein, N. Magdy, Inas A. Abdallah, Hazem E. Hassan*. Precise Simultaneous Quantification of Methadone and Cocaine in Rat Serum and Brain Tissue Samples Following Their Successive i.p. Administration. Journal of Chromatography B. 2017 Mar 24;1048:19-29

Hazem E. Hassan, Jean-Arnaud Keita, Lawrence Narayan, Sean Brady, Richard Frederick, Samuel Carlson, Karen Glass, Senthil Natesan, Thomm Buttolph and Tamer E. Fandy*. The combination of dimethoxycurcumin with DNA methylation inhibitor enhances gene re-expression of promoter-methylated genes and antagonizes their cytotoxic effect. Epigenetics, 2016 Sep 2:1-10

William D. Hedrich, Hazem E. Hassan, and Hongbing Wang*. Insights into CYP2B6-mediated drug-drug interactions. Acta Pharmaceutica Sinica B. 2016 Sep;6(5):413-425

Dilini C. Gunasekara, Mary M. Zheng, Tara Mojtahed, James R. Woods, Tamer E. Fandy, Mark V. Riofski, Carlotta A. Glackin, Hazem E. Hassan, JuliaKirshner, David A. Colby*. 15-Methylene-Eburnamonine Kills Leukemic Stem Cells and Reduces Engraftment in a Humanized Bone Marrow Xenograft Mouse Model of Leukemia. ChemMedChem. 2016 Sep 28. doi: 10.1002/cmdc.201600334. [Epub ahead of print]

Inas A. Abdallah, Peng Huang, Jing Liu, David Y. Lee, Lee-Yuan Liu-Chen, Hazem E. Hassan*. Development and validation of a high performance liquid chromatography quantification method of levo-tetrahydropalmatine and its metabolites in plasma and brain tissues: application to a pharmacokinetic study. Biomedical Chromatography. 2017 Apr;31(4). doi: 10.1002/bmc.3850. Epub 2016 Oct 9

Inas A. Abdallah, Dana H. Hammell, Audra L. Stinchcomb*, Hazem E. Hassan*. A fully validated LC–MS/MS method for simultaneous determination of nicotine and its metabolite cotinine in human serum and its application to a pharmacokinetic study after using nicotine transdermal drug delivery systems with standard heat application in adult smokers. Journal of Chromatography B. 2016 May 1;1020:67-77

Inas A. Abdallah, Dana H. Hammell, Hazem E. Hassan*, Audra L. Stinchcomb*. Norelgestromin/Ethinyl Estradiol Intravenous Infusion Formulation Optimization, Stability and Compatibility Testing: A Case Study to Overcome Polysorbate 80 Interference in Chromatographic Analysis. Journal of Pharmaceutical and Biomedical Analysis. 2016 Jun 5;125:145-53

William D. Hedrich, Jingwei Xiao, Scott Heyward, Yao Zhang, Junran Zhang, Maria R. Baer, Hazem E. Hassan, and Hongbing Wang*. Activation of the constitutive androstrane receptor increases the benefit-risk ratio of CHOP-based treatment of lymphomas. Molecular Cancer Therapeutics. 2016 Mar;15(3):392-401

Tamer E. Fandy, Inas Abdallah, Maan Khayat, David A. Colby and Hazem E. Hassan*. In Vitro Characterization of Transport and Metabolism of the Alkaloids: Vincamine, Vinpocetine and Eburnamonine. Cancer Chemotherapy Pharmacology. 2016 Feb;77(2):259-67

Robert Gharavi, William Hedrich, Hongbing Wang and Hazem E. Hassan*. Transporter-Mediated Disposition of Opioids: Implications for Clinical Drug Interactions. Pharmaceutical Research. 2015 Aug;32(8):2477-502

Hazem E. Hassan, Samuel Carlson, Inas Abdallah, Thomm Buttolph, Karen C. Glass and Tamer E. Fandy*. Curcumin and Dimethoxycurcumin Induced Epigenetic Changes in Leukemia Cells. Pharmaceutical Research. 2015 Mar;32(3):863-75

L. Marcela Merchan#; Hazem E. Hassan#; Michael L. Terrin, David A. Kaufman, Laurence S. Magder, Sagar Shukla, Natalie D. Eddington, and Rose M. Viscardi et al., Pharmacokinetics, Microbial Response, and Pulmonary Outcomes of Multi-dose Intravenous Azithromycin in Preterm Infants at Risk for Ureaplasma Respiratory Colonization. Antimicrobial Agents and Chemotherapy. 2015 Jan;59(1):570-8

Tianxia Li,, Dejun Yang, Shijun Zhong, Joseph Thomas, Fengtian Xue, Jingnan Liu, Lingbo Kong, Pamela Voulalas, Hazem E. Hassan, Jae-Sung Park, Alexander D. MacKerell Jr. and Wanli W. Smith*. Identification and evaluation of novel LRRK2 GTP-binding inhibitors in Parkinson’s disease models. Human Molecular Genetics. 2014 Dec 1;23(23):6212-22

Mingming Yu, Hazem E. Hassan, Kenneth S. Bauer, Deanna L. Kelly and Jia Bei Wang*. Simultaneous Determination of L-tetrahydropalmatine and Cocaine in Human Plasma by Simple UPLC-FLD Method: Application in Clinical Studies. Journal of Chromatography B. 2014 Aug 15;965:39-44

Matthew D. Metcalf, Andrew D. Rosicky, Hazem E. Hassan, Natalie D. Eddington, Andrew Coop, Christopher W. Cunningham*, Susan L. Mercer*. Opioids and efflux transporters. Part 4: Influence of N-substitution on P-glycoprotein substrate activity of noroxymorphone analogues. Bioorganic & Medicinal Chemistry Letters. 2014 Aug 1;24(15):3592-5

Hazem E Hassan, Alan L Myers, Insong J Lee, Hongbing Wang, Clifford W. Mason, Michael Sinz, and Natalie D. Eddington*. Induction of Xenobiotic Receptors, Transporters and Drug Metabolizing Enzymes by Oxycodone. Drug Metabolism and Disposition. 2013 May;41(5):1060-9. Featured on the cover of the May issue.

Rose M. Viscardi*, Ahmed A. Othman, Hazem E. Hassan, Natalie D. Eddington, Elias Abebe, Michael L. Terrin, David A. Kaufman, and Ken B. Waites. Azithromycin to Prevent Bronchopulmonary Dysplasia in Ureaplasma-infected Preterm Infants: Pharmacokinetics, Safety, Microbial Response, and Clinical Outcomes of 20 mg/kg Single Intravenous Dose. Antimicrobial Agents and Chemotherapy. 2013 May;57(5):2127-33

Fahima M. Hashem, Ahmad M. A. Massoud, Abdullah M. Melokheya, Hazem E. Hassan, Kamal Abd El-Fattah Badr, Mohamed Dawoud*. Formulation and Clinical Efficacy of Myrrh Extract in Hard Gelatin Capsules. Journal of Biologically Active Products from Nature. 2013 (2231): 1866-1874

Jillissa C. Molnari, Hazem E. Hassan, Bryant M Moeller, Alan L Myers*. Pharmacokinetics of Bupropion Following Repeated Administration of Sertraline in Mice. European Journal of Drug Metabolism and Pharmacokinetics. 2012 37(1):57-63

Hazem E. Hassan, Ahmed A. Othman, Natalie D. Eddington, Ken B. Waites, David A. Kaufman, Karen D. Fairchild, Michael E. Terrin and Rose M. Viscardi*. Pharmacokinetics, Safety, and Biologic Effects of Azithromycin in Extremely Preterm Infants at High Risk for Ureaplasma Colonization and Bronchopulmonary Dysplasia. Journal of Clinical Pharmacology. 2011 Sep;51(9):1264-75

Jillissa C.  Molnari, Hazem E. Hassan, Bryant M Moeller, Alan L Myers*. Drug interaction study between bupropion and ticlopidine in male CF-1 mice. Biological and Pharmaceutical Bulletin. 2011;34(3):447-51

Linhao Li, Hazem E. Hassan, Antonia Tolson, Stephen S. Ferguson, Natalie D. Eddington, and Hongbing Wang*. Differential Activation of Pregnane X Receptor and Constitutive Androstane Receptor by Buprenorphine in Primary Human Hepatocytes and HepG2 cells. Journal of Pharmacology and Experimental Therapeutics. 2010 Dec;335(3):562-71

Hazem E Hassan, Alan L Myers, Insong J Lee, Hengang Chen, Andrew Coop, and Natalie D. Eddington*. Regulation of Gene Expression in Brain Tissues of Rats Chronically Treated by The Highly Abused Opioid Agonist, Oxycodone: Microarray Profiling and Gene Mapping Analysis. Drug Metabolism and Disposition. 2010 Jan;38(1):157-67

Clifford W. Mason, Hazem E. Hassan, Kang-Pil Kim, Jianjing Cao, Natalie D. Eddington, Amy H. Newman, and Pamela Voulalas*. Characterization of the transport, metabolism, and pharmacokinetics of the dopamine D3 receptor selective fluorenyl amides and 2-pyridylphenyl amides developed for treatment of psychostimulant abuse. Journal of Pharmacology and Experimental Therapeutics. 2010 Jun;333(3):854-64

Alan L. Myers, Hazem E. Hassan, Insong J. Lee, Natalie D. Eddington*. Chronic Administration of Oxycodone Alters the Gene Expression of Several Drug Metabolizing Enzymes in Sprague-Dawley Rats, Including Glutathione S-Transferase A-5 (rGSTA5). Journal of Pharmacy and Pharmacology. 2010 Feb;62(2):189-96

Mohamed Nasr* and Hazem E. Hassan. Pharmacokinetics and Bioequivalence Evaluation of Two Omeprazole Enteric-coated Formulations in Healthy Egyptian Male Volunteers. Journal of Applied Sciences Research. 2009, 5(9): 1190-1194

Hazem E. Hassan, Alan L. Myers, Andrew Coop and Natalie D. Eddington*. Differential Involvement of P-glycoprotein (ABCB1) in Permeability, Tissue Distribution and Antinociceptive Activity of Methadone, Buprenorphine and Diprenorphine: In vitro and In vivo Evaluation. Journal of Pharmaceutical Sciences. 2009 Dec;98(12):4928-40

Hazem E. Hassan, Susan L. Mercer, Christopher W. Cunningham, Andrew Coop and Natalie D. Eddington*. Evaluation of the P-glycoprotein Affinity Status of a Series of Morphine Analogs Using P-gp ATPase Activity Assay and mdr1a/b (-/-) Mice: Comparative Study with Meperidine Analogs. International Journal of Pharmaceutics. 2009 Jun 22;375(1-2):48-54

Zeynep S. Teksin, Insong J. Lee, Noble N. Nemieboka, Ahmed A. Othman, Vijay V. Upreti, Hazem E. Hassan, Shariq S. Syed, Thomas E. Prisinzano, Natalie D. Eddington*. Evaluation of the transport, in vitro metabolism and pharmacokinetics of Salvinorin A, a potent hallucinogen. European Journal of Pharmaceutics and Biopharmaceutics. 2009 Jun;72(2):471-7

Lisa D. Coles, Insong J. Lee, Hazem E. Hassan and Natalie D. Eddington*. Distribution of saquinavir, methadone, and buprenorphine in maternal brain, placenta, and fetus during two different estational stages of pregnancy in mice. Journal of Pharmaceutical Sciences. 2009 Aug;98(8):2832-46

Christopher W. Cunningham, Susan L. Mercer, Hazem E. Hassan, John R Taynor, Natalie D. Eddington and Andrew Coop*. Opioids and efflux transporters. Part 2: P-glycoprotein substrate activity of 3- and 6-substituted morphine analogs. Journal of Medicinal Chemistry. 2008 Apr 10;51(7):2316-20

Hazem E. Hassan, Andrew Coop and Natalie D. Eddington*. Oxycodone induces overexpression of P-glycoprotein (ABCB1) and affects paclitaxel’s tissue distribution in Sprague Dawley rats. Journal of Pharmaceutical Sciences. 2007 Sep;96(9):2494-506

Susan L. Mercer, Hazem E. Hassan, Christopher W. Cunningham, Natalie D. Eddington and Andrew Coop*. Opioids and efflux transporters. Part 1: P-Glycoprotein substrate activity of N-substituted analogs of meperidine. Bioorganic & Medicinal Chemistry Letters. 2007 Mar 1;17(5):1160-2

Book Chapter

Robert Gharavi and Hazem E. Hassan. “Genomics Driven Trends for Disease Prevention and Treatment for Better Healthcare”. Chapter 3: Genomics and Drug Transporters and Application in Drug Discovery and Development. Springer Publishing Group, In Press.

Conference Proceedings

  1. Soo Hyeon Shin, Mingming Yu, Sherin Thomas, Dana C. Hammell, Priyanka Ghosh, Sam G. Raney, Hazem E. Hassan, Audra L. Stinchcomb. Evaluation of Level A In Vitro In Vivo Correlations (IVIVC) for Nicotine and Fentanyl Transdermal Delivery Systems with Transient Heat Exposure by Using Multiple Approaches. Barrier Function of Mammalian Skin Gordon Research Conference, Waterville Valley, NH. 2017

  2. Sagar Shukla, Sherin Thomas, Dana Hammell, Annette Bunge, Hazem E. Hassan, Audra L. Stinchcomb. In Vivo Evaluation of Lidocaine Bioavailability from Two Topical Patch Products by Pharmacokinetic and Skin (Tape) Stripping Analyses. Barrier Function of Mammalian Skin Gordon Research Conference, Waterville Valley, NH. 2017

  3. Sherin Thomas, Priyanka Ghosh, Sam G. Raney, Dana C. Hammell, Hazem E. Hassan, Audra L. Stinchcomb. In Vitro Evaluation of a Buprenorphine Transdermal Delivery System with Transient Heat Exposure and the Correlation of In Vitro Results with Existing In Vivo Results. Barrier Function of Mammalian Skin Gordon Research Conference, Waterville Valley, NH. 2017

  4. Qingzhao Zhang, Priyanka Ghosh, Sam G. Raney, Dana C. Hammell, Hazem E. Hassan, Audra L. Stinchcomb. Characterization of the Cutaneous Pharmacokinetics of Three Metronidazole Topical Drug Products Evaluated by an In Vitro Permeation Test (IVPT) with Excised Human Skin. Barrier Function of Mammalian Skin Gordon Research Conference, Waterville Valley, NH. 2017

  5. Hazem E. Hassan, Vijay Ivaturi, Joga Gobburu, Thomas Green. Currently Recommended Dosage Regimens For Meropenem in Children With Pseudomonas Infections May Fail To Meet Serum Concentration Targets. Annual meeting of the American Society of Clinical Pharmacology (ASCPT). Washington D.C. 2017. Selected as a TOP Poster

  6. Anne Heatherington, Karthik Venkatakrishnan, Shruti Agrawal, Islam Younis, Hazem E. Hassan. Hot Topics Initiative: Highlights from 2016. Annual meeting of the American Society of Clinical Pharmacology (ASCPT). Washington D.C. 2017.

  7. Sagar Shukla, Sam G. Raney, Priyanka Ghosh, Hazem E. Hassan, Annette Bunge, Audra L. Stinchcomb. Evaluation of Two Lidocaine Topical Patch 5% Products by Cutaneous Pharmacokinetic Methods: In Vitro Tape Stripping and In Vitro Permeation Testing. Annual meeting of the American Association of Pharmaceutical Scientists (AAPS). Denver, CO. 2016

  8. Mingming Yu, Soo Hyeon Shin, Dana C. Hammell, Hazem E. Hassan, Audra. L. Stinchcomb. Pharmacokinetics of Fentanyl after Using Reference and Generic Transdermal Fentanyl Patches With and Without Standardized Heat Application in Healthy Human Volunteers. Annual meeting of the American Association of Pharmaceutical Scientists (AAPS). Denver, CO. 2016

  9. Sherin Thomas, Priyanka Ghosh, Sam G. Raney, Dana C. Hammell, Hazem E. Hassan, Audra L. Stinchcomb. Effect of Controlled Heat Application on Topical Diclofenac Formulations Evaluated by In Vitro Permeation Tests (IVPT) using Porcine and Human Skin. Annual meeting of the American Association of Pharmaceutical Scientists (AAPS). Denver, CO. 2016

  10. Soo Hyeon Shin, Mingming Yu, Caroline Strasinger, Dana C. Hammell, Hazem E. Hassan, Audra L. Stinchcomb. Absolute Bioavailability, Pharmacokinetic and Residual Drug Analysis of Two Fentanyl Transdermal Delivery Systems and its Correlation to In Vitro Permeation Tests. Annual meeting of the American Association of Pharmaceutical Scientists (AAPS). Denver, CO. 2016

  11. David S. Nakhla, Lobna A. Hussein, N. Magdy, Inas A. Abdallah, Hazem E. Hassan. Precise High Performance Liquid Chromatography Technique for Simultaneous Quantitation of Methadone and Cocaine in Rat Serum and Brain Tissue Samples. Annual meeting of the American Association of Pharmaceutical Scientists (AAPS). Denver, CO. 2016

  12. Soo Hyeon Shin, Mingming Yu, Juliana C. Quarterman, Dana C. Hammell, Hazem E. Hassan, Audra L. Stinchcomb. In Vitro and In Vivo Evaluation of Three Fentanyl Transdermal Delivery Systems In Conjunction With Transient Heat Exposure. Annual meeting of the American Association of Pharmaceutical Scientists (AAPS). Denver, CO. 2016

  13. Shamia Faison, William D. Hedrich, Robert Gharavi, Hongbing Wang, Jia Bei Wang, Hazem E. Hassan. “Levo-tetrahydropalmatine does not affect the pharmacokinetics of concomitantly administered cocaine in rats.” Annual Meeting of the American College of Clinical Pharmacology (ACCP). Bethesda, MD. 2016.

  14. William D. Hedrich, Linhao Li, Scott Heyward, Maria R. Baer, Hazem E. Hassan, and Hongbing Wang. “Targeting the constitutive androstane receptor as a novel method for treating hematologic malignancies”. Meeting of the Graduate Pharmaceutics Education Network (GPEN). Lawrence, KS. 2016. Podium presentation.

  15. William D. Hedrich, Linhao Li, Scott Heyward, Maria R. Baer, Hazem E. Hassan, and Hongbing Wang. “Targeting the constitutive androstane receptor as a novel method for treating hematologic malignancies.” Annual meeting of the American Association of Pharmaceutical Scientists (AAPS). Denver, CO. 2016

  16. William D. Hedrich, David S. Nakhla, Hongbing Wang, and Hazem E. Hassan. “Administration of methadone and oxycodone alters the expression of drug metabolizing enzymes and transporters affecting the disposition of cocaine.” Annual meeting of the American Association of Pharmaceutical Scientists (AAPS). Denver, CO. 2016

  17. Soo Hyeon Shin, Priyanka Ghosh, Bryan Newman, Sam G. Raney, Dana C. Hammell, Hazem E. Hassan, Audra L. Stinchcomb. Effect of heat on nicotine and fentanyl transdermal delivery evaluated in vitro using different skin/membranes. Perspectives in Percutaneous Penetration meeting, La Grande Motte, France, March, 2016

  18. William D. Hedrich, Jingwei Xiao, Scott Heyward, Yao Zhang, Junran Zhang, Maria R. Baer, Hazem E. Hassan, and Hongbing Wang. “Combination of CHOP and an agonist of the constitutive androstane receptor increases the therapeutic index of lymphoma treatment”. Graduate Research Conference, University of Maryland, Baltimore 2016. Poster. Outstanding Presentation Award.

  19. William D. Hedrich, Jingwei Xiao, Scott Heyward, Yao Zhang, Junran Zhang, Maria R. Baer, Hazem E. Hassan, and Hongbing Wang. “Combination of CHOP and an agonist of the constitutive androstane receptor increases the therapeutic index of lymphoma treatment”. Frontiers at the Chemistry-Biology Interface Symposium, Johns Hopkins University. May, 2016.

  20. William D. Hedrich, Jingwei Xiao, Scott Heyward, Yao Zhang, Junran Zhang, Maria R. Baer, Hazem E. Hassan, and Hongbing Wang. “Combination of CHOP and an agonist of the constitutive androstane receptor increases the therapeutic index of lymphoma treatment”. UMB-UMBC Partnership Symposium. University of Maryland, Baltimore. April, 2016.

  21. Hazem E. Hassan, Jean-Arnaud Keita, Lawrence Narayan, Sean Brady, Richard Frederick, Samuel Carlson, Karen Glass, Thomm Buttolph and Tamer Fandy. The Interactive Effects of Dimethoxycurcumin and Decitabine in Leukemia Cells. Annual Meeting of the American Association of Pharmaceutical Scientists (AAPS), Orlando, FL, October, 2015

  22. Sherin Thomas, Soo Hyeon Shin, Inas Abdallah, Priyanka Ghosh, Bryan Newman, Sam G. Raney, Dana C. Hammell, Samer S. El-Kamary, Wilbur H. Chen, Hazem E. Hassan, Audra L. Stinchcomb. A Pharmacokinetic Study of the Effect of a Standardized Exposure to Heat on Nicotine Transdermal Delivery in Adult Smokers. Annual Meeting of the American Association of Pharmaceutical Scientists (AAPS), Orlando, FL, October, 2015

  23. Soo Hyeon Shin, Sherin Thomas, Inas Abdallah, Priyanka Ghosh, Bryan Newman, Sam G. Raney, Dana C. Hammell, Hazem E. Hassan, Audra L. Stinchcomb. In Vitro/In Vivo Correlation (IVIVC) of Bioavailability from Nicotine Transdermal Drug Delivery Systems under the Influence of Heat. Annual Meeting of the American Association of Pharmaceutical Scientists (AAPS), Orlando, FL, October, 2015

  24. Soo Hyeon Shin, Priyanka Ghosh, Bryan Newman, Sam G. Raney, Dana C. Hammell, Hazem E. Hassan, Audra L. Stinchcomb. Assessing Bioavailability and Estimating Bioequivalence of Acyclovir Creams by In Vitro Permeation Tests with Excised Human Skin. Annual Meeting of the American Association of Pharmaceutical Scientists (AAPS), Orlando, FL, October, 2015

  25. Inas A. Abdallah, Dana C. Hammell, Hazem E. Hassan, Audra L. Stinchcomb. Preformulation Analysis and Product Stability of Norelgestromin/Ethinyl Estradiol Intravenous Infusion. Annual Meeting of the American Association of Pharmaceutical Scientists (AAPS), Orlando, FL, October, 2015

  26. Sagar Shukla, Hazem E. Hassan, Sam G. Raney, Bryan Newman, Priyanka Ghosh, Annette Bunge, Audra L. Stinchcomb. Evaluation of Diclofenac Epolamine 1.3% and Lidocaine 5% Topical Patches by Dermal Pharmacokinetic Methods: In Vitro Tape Stripping and In Vitro Permeation Testing (IVPT). Annual Meeting of the American Association of Pharmaceutical Scientists (AAPS), Orlando, FL, October, 2015

  27. Raghunadha Reddy Seelam, Michael Terrin, Hazem E. Hassan. Development and Validation of UPLC–MS/MS Assay for The Determination Of Doxycycline In Serum Of Patients With Abdominal Aortic Aneurysm. Annual Meeting of the American Association of Pharmaceutical Scientists (AAPS), Orlando, FL, October, 2015

  28. Hazem Hassan, Jean-Arnaud Keita, Lawrence Narayan, Sean Brady, Richard Frederick, Samuel Carlson, Karen Glass, Thomm Buttolph, and Tamer Fandy. The Interactive Effects of Dimethoxycurcumin and Decitabine in Leukemia Cells. Annual Meeting of the American Association of Pharmaceutical Scientists (AAPS), Orlando, FL, October, 2015

  29. Peng Huang, Inas Abdallah, Jing Liu, Hazem E. Hassan, Wei Xu, William Hedrich, David Y. Lee, Hazem Hassan and Lee-Yuan Liu-Chen. Metabolism of L-tetrahydropalmatine (L-THP) in rats and in vitro effects of its major metabolites on dopamine receptors. Annual meeting of the Society of Neuroscience (SFN), Chicago, IL, October, 2015

  30. Soo Hyeon Shin, Sherin Thomas, Inas Abdallah, Priyanka Ghosh, Bryan Newman, Sam G. Raney, Dana C. Hammell, Hazem E. Hassan, Audra L. Stinchcomb. Evaluation of Bioavailability and In Vitro/In Vivo Correlation of Nicotine Transdermal Drug Delivery Systems Under the Influence of Heat. Gordon research conference (GRC), Barrier Function of Mammalian Skin, Waterville Valley, NH, August 2015

  31. Soo Hyeon Shin, Hazem E. Hassan, Audra L. Stinchcomb, Priyanka Ghosh, Bryan Newman, Sam G. Raney, Robert Lionberger. Influence of Heat on Reference and Generic Transdermal Drug Delivery Systems. CDER Innovation day, Food and Drug Administration (FDA), Rockville, MD, September, 2014

  32. Hazem E. Hassan, Carlson S., Abdallah I., Glass K., Buttolph T and Fandy T.E Curcumin and Dimethoxycurcumin Induced Epigenetic Changes in Leukemia Cells. Annual Meeting of the American Association of Pharmaceutical Scientists (AAPS), San Diego, CA, November, 2014

  33. Inas Abdallah, Priyanka Ghosh, Brian Newman, Sam Raney, Audra Stinchcomb*, Hazem E. Hassan*. LC/MS/MS Determination of Nicotine and Its Metabolite Cotinine in Human Plasma. Annual Meeting of the American Association of Pharmaceutical Scientists (AAPS), San Diego, CA, November, 2014

  34. Soo Hyeon Shin, Priyanka Ghosh, Brian Newman, Sam Raney, Hazem E. Hassan, Audra L. Stinchcomb. Influence of Heat on Reference and Generic Transdermal Drug Delivery Systems. Annual Meeting of the American Association of Pharmaceutical Scientists (AAPS), San Diego, CA, November, 2014

  35. William D. Hedrich, Jingwei Xiao, Scott Heyward, Hazem E. Hassan, and Hongbing Wang. Activation of the constitutive androstane receptor increases the benefit-risk ratio of CHOP-based treatment of Lymphomas. Annual Meeting of the International Society for the Study of Xenobiotics (ISSX), San Francisco, CA, October, 2014

  36. Andrew D. Rosicky, Matthew D. Metcalf, Hazem E. Hassan, Natalie D. Eddington, Andrew Coop, Susan L. Mercer, Christopher W. Cunningham. Evaluation of a Mathematical Model for P-gp Substrates: Application to Opioid Receptor Ligands. Annual meeting of Behavior, Biology, and Chemistry (BBC), San Antonio, TX, March, 2014

  37. Hazem E. Hassan, Alan Myers, Insong Lee, Clifford Mason, Natalie D Eddington. Oxycodone Induces an Array of Xenobiotic Receptors, Transporters and Drug Metabolizing Enzymes in Brain and Liver Tissues of Rats. Annual meeting of Behavior, Biology, and Chemistry (BBC), San Antonio, TX, March, 2014

  38. Inas A. Abdallah, Maan Khayat, Hazem E. Hassan. In vitro Characterization of Transport and Metabolism of Vinca/Eburnane alkaloids used for the Treatment of Cerebrovascular Diseases. School of Pharmacy Research Day, University of Maryland, Baltimore, May, 2014

  39. Hazem E. Hassan, Natalie Eddington, L Marcela Merchan, Michael Terrin, Susan Dulkerian, Namasivayam Ambalavanan, Pamela Donohue, David Kaufman, Robert Schelonka, Larry Magder, Ken Waites and Rose M. Viscardi. Population Pharmacokinetics of Azithromycin in Preterm Neonates. Annual Meeting of the American Association of Pharmaceutical Scientists (AAPS), San Antonio, TX, November, 2013

  40. L Marcela Merchan, Michael Terrin, Hazem E. Hassan, Natalie Eddington, Susan Dulkerian, Namasivayam Ambalavanan, Pamela Donohue, David Kaufman, Robert Schelonka, Larry Magder, Ken Waites, and Rose Viscardi. Azithromycin to prevent BPD in Ureaplasma-Infected Preterms: A Population PK and Safety Trial. The annual meeting of the Pediatric Academic Societies, Washington D.C., May, 2013

  41. Shamia L. Faison, Hazem E. Hassan, Natalie D. Eddington, Jia Bei Wang. L-THP- Cocaine Drug-drug Interaction in Spraque Dawley Rats. School of Pharmacy Research Day, University of Maryland, Baltimore, May, 2012

  42. Hazem E. Hassan, Ahmed A. Othman, Natalie D. Eddington, Ken B. Waites, David A. Kaufman, Karen D. Fairchild, Michael E. Terrin and Rose M. Viscardi. Azithromycin for treatment of Bronchopulmonary Dysplasia in Preterm Neonates. School of Pharmacy Research Day, University of Maryland, Baltimore, May, 2011

  43. Hazem E. Hassan, ON Uddin ND Eddington, PJ Voulalas. Gestation alters membrane localization of blood-brain barrier transporters and modulates maternal brain distribution and efficacy of antiepileptic drugs, American Epilepsy Society Meeting, Baltimore, MD, December 2011.

  44. Voulalas PJ, Hazem E. Hassan, SL Faison, ND Eddington. Gestational modulation of P-glycoprotein activity affects distribution of antiepileptic drugs to maternal brain, Annual Meeting of the Society for Neuroscience, Washington, DC, November 2011.

  45. Elias Abebe, Rose M Viscardi, Hazem E. Hassan, Michael L Terrin, Natalie D Eddington, David Kaufman, and Ken B Waites. Azithromycin to Prevent Bronchopulmonary Dysplasia in Ureaplasma-infected Pre-terms: Single Dose Pharmacokinetics Study. Joint meeting of the Pediatric Academic Societies and Asian Society for Pediatric Research, Denver, CO, May, 2011.

  46. Hazem E. Hassan, Ahmed A. Othman, Natalie D. Eddington, Ken B. Waites, David A. Kaufman, Karen D. Fairchild, Michael E. Terrin and Rose M. Viscardi. Evaluation of Single Dose Azithromycin for Eradication of Ureaplasma and Prevention of Bronchopulmonary Dysplasia in Preterm Neonates. The International Pharmaceutical Federation – Pharmaceutical Scientists World Congress/American Association of Pharmaceutical Scientists (FIP PSWC/AAPS) meeting, New Orleans, LA, November, 2010.

  47. Elias Abebe, Rose M Viscardi, Hazem E. Hassan, Michael L Terrin, Natalie D Eddington, David Kaufman, and Ken B Waites. Azithromycin to Prevent Bronchopulmonary Dysplasia in Ureaplasma-infected Pre-terms: Single Dose Pharmacokinetics Study. Annual meeting of the American Academy of Pediatrics, San Francisco, CA, October, 2010.

  48. Pamela J. Voulalas, Lisa D. Coles, Hazem E. Hassan, Natalie D. Eddington. Gestational modulation of P-glycoprotein activity in mouse brain. Annual meeting of the Society of Neuroscience, San Diego, CA, November, 2010.

  49. Pamela J. Voulalas, Lisa D. Coles, Olivia Uddin, Hazem E. Hassan, Natalie D. Eddington. Modulation of ABC transporter localization and activity during gestation. GRC, “Barrier of the CNS”, New London, NH. June, 2010

  50. Linhao Li, Hazem E. Hassan, Antonia Tolson, Stephen S. Ferguson, Natalie D. Eddington, and Hongbing Wang. Differential Activation of Pregnane X Receptor and Constitutive Androstane Receptor by Buprenorphine in Primary Human Hepatocytes and HepG2 cells. School of Pharmacy Research Day, University of Maryland, Baltimore, May, 2010

  51. Christopher W. Cunningham, Hazem E. Hassan, Susan L. Mercer, John R Taynor, Natalie D. Eddington and Andrew Coop. Morphine analogs and P-glycoproteins. Medicinal & Bioorganic Chemistry Foundation, winter meeting. Steamboat Springs, CO, USA, January, 2009

  52. Zeynep S. Teksin, Hazem E. Hassan, Thomas E. Prisinzano and Natalie D. Eddington. Evaluation of the P-glycoprotein (Abcb1) Affinity status of salvinorin A. Annual meeting of the controlled release society (CRS), NY, USA, July, 2008

  53. Susan L. Mercer, Christopher W. Cunningham, Hazem E. Hassan, Natalie D. Eddington and Andrew Coop. The relative activity of meperidine analogs as P-glycoprotein substrates. International Narcotics Research Conference, Berlin, Germany, July 2007.

  54. Alan L. Myers, Hazem E. Hassan, Insong J. Lee, Natalie D. Eddington. Repeated administration of oxycodone alters the expression of drug metabolizing enzymes in the liver of Sprague-Dawley rats. Annual Meeting of the Federation of The American Societies for Experimental Biology (FASEB), Washington D.C., April, 2007

  55. Hazem E. Hassan, Alan L. Myers, Insong J. Lee, Andrew Coop and Natalie D. Eddington. Upregulation of Abcg2 Expression by Chronic Administration of Oxycodone Hinders Mitoxantrone Brain Uptake in Rats. Annual Meeting of the American Association of Pharmaceutical Scientists (AAPS) – Drug Transporters in ADME workshop, Bethesda, MD, March 5-7, 2007

  56. Lisa D. Coles, Insong J. Lee, Hazem E. Hassan, Natalie D. Eddington. Gestational-Induced Alterations in Brain Distribution of the P-gp Substrates, Saquinavir and Methadone in Mice. Annual Meeting of the American Association of Pharmaceutical Scientists (AAPS) – Drug Transporters in ADME workshop, Bethesda, MD, March, 2007

    Hazem E. Hassan. Oxycodone Regulates Transporters Expression in The Brain and Affects the Brain Uptake of Selected Anticancer Agents PSC Department Retreat, School of Pharmacy, May, 2007

  57. Hazem E. Hassan, Alan L. Myers, Insong J. Lee, Andrew Coop and Natalie D. Eddington. Oxycodone Regulates Transporters Expression in The Brain and Affects the Brain Uptake of Selected Anticancer Agents. Pharmacy Showcase, University of Maryland, Baltimore, May, 2007

  58. Hazem E. Hassan, Alan L. Myers, Insong J. Lee, Andrew Coop and Natalie D. Eddington. Influence of P-glycoprotein on Tolerance Development to Oxycodone in Rodents. Poster and podium presentations, Annual Meeting of the American Association of Pharmaceutical Scientists (AAPS), San Antonio, TX, October, 2006

  59. Susan L. Mercer, Christopher W. Cunningham, Hazem E. Hassan, Natalie D. Eddington and Andrew Coop. The relative activity of opioids as P-glycoprotein substrates. Abstracts of the College on Problems of Drug Dependence, Scottsdale, AZ, July, 2006.

  60. Christopher W. Cunningham, Hazem E. Hassan, Natalie D. Eddington and Andrew Coop. Diminished P-gp substrate activity of 3- and 6-substituted morphine analogs. International Narcotics Research Conference, St. Paul, MN, July, 2006.

  61. Hazem E. Hassan, Christopher W. Cunningham, Andrew Coop and Natalie D. Eddington. Studying The Effect of P-glycoprotein and MRP1 on The Uptake, Transport and Tolerance Development to Selected Opioids. Graduate Research Day, University of Maryland, Baltimore, May, 2006

  62. Christopher W. Cunningham, Hazem E. Hassan, Natalie D. Eddington and Andrew Coop. Effect of 3- and 6-substitutions on P-gp substrate activity of morphine analogs. Graduate Research Day, University of Maryland, Baltimore, May, 2006

  63. Susan L. Mercer, Christopher W. Cunningham, Hazem E. Hassan, Natalie D. Eddington and Andrew Coop. The relative activity of meperidine analogs as P-glycoprotein substrates Graduate Research Day, University of Maryland, Baltimore, May, 2006

  64. Hazem E. Hassan, Andrew Coop and Natalie D. Eddington. Monitoring of Antinociceptive Effect and Brain P-glycoprotein Expression in Oxycodone Tolerant Rats. Annual Meeting of the American Association of Pharmaceutical Scientists (AAPS), Nashville, TN, November 6-10, 2005

  65. Hazem E. Hassan, Christopher W. Cunningham, Andrew Coop and Natalie D. Eddington. Effect of Potent and Specific P-gp and MRP Inhibitors on the Transport of Selected Opioids Across Caco-2 Cells and MDCKII-MRP1 Overexpressing Cells. Annual Meeting of the American Association of Pharmaceutical Scientists (AAPS), Nashville, TN, November 6-10, 2005

  66. Shariq Syed, G. Kamimori, Praveen Jadhav, Jogga. Gobburu, Hazem E. Hassan, Vijay. Upreti and Natalie D. Eddington. Population Pharmacokinetics of Caffeine Administered in Chewing Gum to Healthy Volunteers. Annual Meeting of the American Association of Pharmaceutical Scientists (AAPS), Nashville, TN, November, 2005

  67. Hazem E. Hassan, Christopher W. Cunningham, Andrew Coop and Natalie D. Eddington. Effect of The ABC Transport Proteins on The Uptake, Transport and Tolerance Development to Selected Opioids. Annual Meeting of the International Society for the Study of Xenobiotics (ISSX), Maui, Hawaii, October, 2005

  68. Hazem E. Hassan, Andrew Coop and Natalie D. Eddington. Monitoring of Antinociceptive Effect and Brain P-gp Expression in Oxycodone Tolerant Rats. Pharmacy Research Day, University of Maryland, Baltimore, May, 2005

  69. Shariq. Syed, Hazem E.Hassan, Vijay. Upreti, G. Kamimori and Natalie D. Eddington. Pharmacokinetics of High-Dose Caffeine Administered in Chewing Gum to Normal Healthy Volunteers. Annual Meeting of the American Association of Pharmaceutical Scientists (AAPS), Baltimore, MD, November, 2004

  70. Hazem E. Hassan, Andrew Coop and Natalie D. Eddington. Potential Role of Multidrug Resistance (MDR) Proteins in Oxycodone Transport Across Caco-2 Cells. Annual Meeting of American Association of Pharmaceutical Scientists (AAPS), Baltimore, MD, November, 2004

  71. Hazem E. Hassan, Andrew Coop and Natalie D. Eddington. Influence of Efflux Transporters on Oxycodone Transport Across Caco-2 Cells. Pharmacy Research Day, University of Maryland, Baltimore, May, 2004

  72. Hazem E. Hassan, Andrew Coop and Natalie D. Eddington. Influence of Efflux Transporters on Oxycodone Transport Across Caco-2 Cells. Graduate Research Conference, University of Maryland, Baltimore County, April, 2004